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30 November 2010

New inhaler delivers significantly more drug to the deep lung, regardless of strength of breath

Cambridge Consultants and Sun Pharma Advanced Research Company Ltd develop a high performance, easy to use dry powder inhaler

Cambridge Consultants, a leading technology product design and development firm, has developed a new high efficiency, easy to use dry powder inhaler with Sun Pharma Advanced Research Company Ltd. ("SPARC") one of India's leading pharmaceutical research companies, and Design Directions, a leading Design House in India. The inhaler has a uniform delivery profile that ensures the full intended metered dose of the drug is administered to the deep lung, regardless of the strength of the patient's intake of breath.

The device employs a novel de-agglomeration engine to separate the drug from the lactose 'carrier' particles. Based on a highly efficient airway design, the patented drug separation mechanism has successfully completed clinical trials and demonstrated that it is capable of delivering significantly more of the drug to the deep lung than traditional inhalers. In practice, this will minimise side effects from drug build-up in the back of the throat, reduce non-systemic load and wastage, and means almost 50% less active drug needs pre-loading into the device in comparison to a standard inhaler.

This step change in inhaler technology is a reliable and easy to use device, particularly for patients with impaired lung function or those using the inhaler during an asthma attack – overcoming any patient concerns about the ability to use the device effectively.

In addition to its novel drug delivery mechanism, the device integrates a number of user-friendly design features. These include a numerical dose counter to indicate at a glance how many more doses are left in the inhaler before it runs out, a luminous feature to enable users to find the device in the dark and a small pop-out 'braille' button which activates when there are only a few doses remaining. The device gives audible and tactile feedback to indicate the delivery and completion of user steps. The device also features a unique palm-held form, designed to discreetly house the complex dose carriage and delivery system yet remain comfortable to hold and use.

Mr Dilip S. Shanghvi, Chairman and Managing Director of SPARC, commented, "Our search for the right design expertise for this project was global, but Cambridge Consultants stood out to us because of its excellent track record in medical device development. The partnership has worked incredibly well and has enabled us to take the product from initial requirement to market in half the time that such projects usually demand."

Phil Lever, Commercial Director at Cambridge Consultants, added, "We're delighted that SPARC chose to work with us on the technically challenging project as we feel this is a strong endorsement of the world-class development skills we offer, and we are very proud of the inhaler that has been developed as a result of this collaborative partnership." Cambridge Consultants and SPARC are now working together to ready the device for manufacture and the commercial launch is expected in 2011.

Cambridge Consultants will also be demonstrating the device at the Drug Delivery to the Lungs (DDL) 21 conference, Edinburgh International Conference Centre, 8th-10th December 2010.

Notes to editors

Cambridge Consultants develops breakthrough products, creates and licenses intellectual property, and provides business consultancy in technology critical issues for clients worldwide. For more than 50 years, the company has been helping its clients turn business opportunities into commercial successes, whether they are launching first-to-market products, entering new markets or expanding existing markets through the introduction of new technologies. With a team of more than 400 staff, including engineers, scientists, mathematicians and designers, in offices in Cambridge (UK), Boston (USA) and Singapore, Cambridge Consultants offers solutions across a diverse range of industries including medical technology, industrial and consumer products, digital health, energy and wireless communications.

Cambridge Consultants is part of Altran, a global leader in innovation and high-tech engineering consulting which supports companies in the creation and development of their new products and services. With a staff of over 21,000 employees in more than 20 countries, the Group generated revenues of €1,633m in 2013. For more information visit: www.altran.com

About SPARC

Sun Pharma Advanced Research Company Ltd (NSE: SPARC, BSE: 532872) is an international pharmaceutical company engaged in research and development of drugs and delivery systems. More information about the company can be found at www.sunpharma.in.

Press Contacts

Corporate communications
Debbie Mayhew
PR & Communications Manager
Cambridge Consultants
+44 1223 392418
Debbie.Mayhew@CambridgeConsultants.com

European PR agency
David Vindel
Ketchum
+44 20 7611 3660
CambridgeConsultants@ketchum.com

US PR agency
Sarah Hurley
March Communications
+1 617 960 8895
CambridgeConsultants@ketchum.com