Cell and Gene Therapy at Cambridge Consultants
We collaborate with cell and gene therapy development organisations and tool providers to advance their ambitions in the space. Our role is to help revolutionise drug discovery, cell and gene manufacturing processes and equipment – as we strive to enable these life-changing therapies for patients around the world.
Talk to us about your challenge
We work with many ambitious clients
Solving the problem of microbial contamination – using new sensors and AI for real-time detection
Cell and gene therapy and regenerative medicine are regarded as the future – but manufacturing can be hindered by slow, laborious and expensive sterility testing. This whitepaper goes behind the scenes of a significant breakthrough for contamination detection during cell and gene therapy manufacturing. It tells the story of PureSentry, a prototype device for on-line, real-time detection of potential contamination in the manufacturing process for advanced therapies.
The future of process analytics in cell and gene therapy manufacture
The CGT Catapult – established by the UK government’s Innovate UK agency – has formed a consortium to accelerate process analytic technology development and reduce costs in cell and gene therapy manufacturing. The CC cell and gene therapy team is playing a role in helping to ensure that therapies can be developed for use in health services throughout the world.
Understanding the life of a therapeutic cell
Understanding the behaviour of cell therapies once they’ve been administered is crucial to improving patient benefit. We developed a system as a multidisciplinary project between our microfluidics and digital imaging and AI teams to demonstrate our capabilities in EWOD, optics and machine vision. This system allows single cells to be propagated and analysed over the course of days, and analysis of both the cells and also excreted metabolites and cytokines.
Gene therapy delivery to the eye: it’s time to focus on the cutting-edge candidates
Tech, tools & facilities
Cell culture labs
Our life science and synthetic biology facilities are complemented by our recently established cell culture labs. They support our clients in the advanced therapies and medicinal products field to deliver the most advanced drugs on the planet. We’ve equipped them with tools to monitor, grow and store cells which are relevant to cell and gene therapy process development.
Molecular Biology labs
Our microbiology lab enables us to genetically modify micro-organisms and characterise them. Our facilities are containment level 2 rated for handling pathogenic strains and our in-house libraries allow rapid modular DNA construct design and assembly. We are particularly interested in building organisms that are biological sensors for healthcare and industrial biotech applications.
생명 과학 연구실
캠브리지 컨설턴트의 생명 공학 연구실은 Class II 연구실로, 통제되고 규제된 환경에서 의약품, 허가 물질, 생물학적 위험 및 인체 표본을 취급 및 실험하는 목적으로 특수 설계된 시설입니다. 계량계측실은 특히 계측기, 현미경, 제품 테스트 장비를 갖추고 있어 철저한 검증과 시제품 및 제품 품질 보증이 가능합니다.
시제품 (프로토타이핑) 작업실
캠브리지 컨설턴트의 전기 기계 프로토타이핑 작업실에서는 아이디어에 생명력을 불어 넣어줄 기술성을 갖춘 시제품 제작과 시제품의 가치에 대한 확실한 검증이 가능합니다. 모든 작업은 ISO 9001, ISO 13485, ISO 14001 규정에 따라 매우 높은 품질 기준을 유지하고 있습니다. 캠브리지 컨설턴트는 첨단 CNC 밀링(milling) 공작 기계, 절단기(lathes), 용접기, 배선 조립체(wire harness), 케이블 조립 공구 등을 사용하여 부품을 신속히 제작하고 실물 크기에 작동하는 시제품을 소비자 테스트를 위해 조립 할 수 있습니다.
Using hand and machine tools, laser cutters and 3D printers, this is where we create custom parts, build test jigs and fixtures and modify existing components. This means that our engineers can make changes to test pieces and prototypes whenever they need to, 24 hours a day.
Computer-aided design & engineering
Using the latest CAD and CAE systems, we design 3D parts for single tests pieces through to complete production assemblies with thousands of individual components. In addition to maintaining the most up-to-date software, we invest in developing proprietary tools and processes. Meanwhile, data management and version control systems allow us to work anywhere securely and efficiently.
캠브리지 컨설턴트의 광학 연구실에서는 개발 단계 이전에 시제품 디자인과 신규 테크닉을 테스트하며, 주로 사용되는 복잡한 고정밀 광학 레이아웃 구축이 가능합니다. 광학 연구실은 6개의 고사양(high-spec) 광학대(optical bench)와 고전력(4등급) 레이저 작업을 위해 용도 변경이 가능한 인터록 통제 영역, 그리고 간섭측정, 분광학, 저노이즈 형광 이미지화, 광자(光子) 계측을 위한 특수 시설을 갖추고 있습니다. 또한 별도의 레이저 통제 영역으로 분리되어 있어 다수의 실험을 동시에 실시할 수 있기 때문에 당사의 광학 엔지니어들은 측정 장비의 제약 없이 창의적인 솔루션을 개발할 수 있습니다.
미세 유체(Microfluidics) 연구실
캠브리지 컨설턴트의 미세유체(Microfluidics) 연구실은 클린 환경에서 폴리디메틸실록산(PDMS: Polydimethylsiloxane) 미세유체 장비를 단시간 내에 프로토타이핑 할 수 있도록 구성되어 있습니다. 당사는 최신 현미경을 통해 기능 검사 카트리지에 대해 육안 검사를 실시하며 Spraytec 레이저 회절 시스템을 이용하여 입자 크기 분포를 측정합니다.
Meet our cell & gene therapy experts
Providing unique solutions that take advantage of the breadth and depth of our collective knowledge is immensely fulfilling. Our Boston-based biology team includes multiple offerings in cell biology, positioning us to meet the diverse challenges our clients face where biological needs intersect with the computational and engineering arenas.
It has been exciting to work with therapy developers and instrument vendors working at the cutting edge of cell and gene therapy, and to be able to bring CC’s engineering, computing and biology capabilities to help get our clients closer to market. Knowing that our work is ultimately helping patients is immensly satisfying.
Over the last decade, I’ve been inspired and encouraged witnessing the transition from early clinical trials through to commercialisation for CGT developers. To scale and democratise these therapies to meet patient demand, we need new technologies such as automation and novel sensing, and Cambridge Consultants is able to help these come to life.
Making the changes we need to see in this industry – increased accessibility, reliability and throughput – requires so many different types of people. I love working across disciplines and helping bridge the gap between them to create truly life-changing therapeutics for society.
It is fascinating to see how different companies working in the cell and gene therapy space utilize biology in innovative ways. I love being able to showcase our broad range of skills to help companies face their challenges head on, helping companies develop their technology so others can benefit from these ground-breaking innovations.